Department of Entomology
Yoonseong Park

Park, Yoonseong

University Distinguished Professor
32 W. Waters Hall
Manhattan KS 66506
Phone: (785) 532-5763
Fax: (785) 532-6232

parklab logo

Link to Park Lab in Google Site

Link pages (not function yet, under construction)

[Research] [Lab Members] [Lab Meeting] [Journal Club] [Link out]

Education

B.S. Agricultural Biology, Chonbuk National University, Korea, 1991
M.S. Entomology, University of California, Riverside, 1994
Ph.D. Insect Science, University of Arizona, Tucson, 1998
Post Doctoral Associate , University of California, Riverside, 1998 - 2002

Teaching

  • Insect Physiology [ENTOM 875]
  • Insect Morphology [ENTOM 866]
  • Molecular Entomology Laboratory (a part of team taught course)

Research

Arthropod is the largest Phylum on earth in its number and diversity. Many species of arthropods have significant impacts on human life and health. We study molecular physiology of arthropod species to gain fundamental knowledge and to apply the knowledge to improve human life.

1. Arthropod signaling peptides and their receptors.

The peptide signaling system, an ancient cell-cell communication mechanism, appears to be the top upstream commands that modulate various behavioral and physiological events. My research focuses on evolution of neuropepetides, their receptors, and functions. Model arthropods that we study are the species fruitfly (Drosophila melanogaster), red flour beetle (Tribolium castaneum), and blacklegged tick (Ixodes scapularis).

2. Signaling pathways for tick salivary secretion.

Ticks are obligatory ectoparasites that feed on the blood of vertebrate hosts and often transmit pathogens, including bacteria, protozoa, and viruses. The salivary secretions of ticks play an important role in blood feeding by modulating the host response. We investigate neural and hormonal mechanisms controlling salivary secretion, involving multiple neuropeptides and catecholamines.

3. Mechanisms of systemic RNA interference

Publications

(Link to publications in google scholar)

2011 and after

Jung, S-H, J-H Lee, H-S Chae, J-Y Seong, Y. Park, Z-Y Park, and Y-J Kim (2014) Identification of a novel insect neuropeptide, CNMa and its receptor. FEBS Letters 588: 2037-2041.

Kirkpatrick, K., A. T. Marshall, A. P. Smith, J. Koci, Y. Park (2014) Individual differences in impulsive and risky choice: Effects of environmental rearing conditions. Behavioral brain research 269C: 115-127.

Koči, J., L. Šimo, and Y. Park (2014) Autocrine/paracrine dopamine in the salivary glands of the blacklegged tick Ixodes scapularis. J. Insect Physiology 62:39-45

Agrawal, S., M. Kelkenberg, K. Begum, S. Lea, C. E. Williams, K. J. Kramer, R. W. Beeman, Y. Park, S. Muthukrishnan, H. Merzendorfer (2014) Two essential peritrophic matrix proteins mediate matrix barrier functions in the insect midgut. Insect Biochem. Mol. Biol. 49:24-34.

Cho, K-H, I. Daubnerova, Y. Park, D. Zitnan, and M.E. Adams (2014) Secretory competence in a gateway endocrine cell conferred by the orphan nuclear receptor β-FTZ-F1 enables stage-specific ecdysone responses throughout development in Drosophila. Developmental Biology 385:253-262.

Koči, J., P. Ramaseshadri, R. Bolognesi, G. Segers, R. Flannagan, and Y. Park (2014) Ultrastructural changes caused by Snf7 RNAi in larval enterocytes of western corn rootworm (Diabrotica virgifera virgifera Le Conte). PLoS ONE 9(1): e83985. doi:10.1371/journal.pone.0083985.

Šimo, L., Koči, J., Kim, D., and Y. Park (2013) Invertebrate specific D1-like dopamine receptor in control of salivary gland in the black-legged tick, Ixodes scapularis. J. Comparative Neurology 522:2038-2052.

Jiang, H, Z. Wei, R. J. Nachman, and Y. Park (2013) Molecular cloning and functional characterization of the diapause hormone receptor in the corn earworm Helicoverpa zea. Peptides 53:243-249

Alleman, A., Y. Park, and S. Kambhampati (2013) Complete Genome Sequence of the Endosymbiont Blattabacterium from the cockroach Nauphoeta cinerea (Blattodea: Blaberidae). Genomics. http://dx.doi.org/10.1016/j.ygeno.2013.09.003.

Jiang, H., A. Ikhagva, I. Daubnerová, H. Chae,L. Šimo, S-H. Jung, Y-K. Yoon, N-R Lee, Y. J. Seong, D. Žitňan, Y. Park, and Y-J. Kim (2013) Natalisin, a new tachykinin-like signaling system, regulates sexual activity and fecundity in insects. Proc. Nat. Aca. Sci. USA. www.pnas.org/cgi/doi/10.1073/pnas.1310676110. Park as the co-corresponding author

Šimo, L., Koči, J., and Y. Park (2013) Receptors for the neuropeptides, myoinhibitory peptide and SIFamide, in control of the salivary glands of the blacklegged tick Ixodes scapularis. Insect Biochem. Mol. Biol., 43:376-387.

Koči, J., L. Šimo, and Y. Park (2013) Validation of internal reference genes for real-time quantitative PCR studies in the tick Ixodes scapularis. J. Medical Entomology, 50:79-84.

Šimo, L., D. Žitnan, and Y. Park (2013) Neural systems of ticks. pp. 309-367. In Biology of Ticks (2nd edition). Oxford University Press in New York City, New York, USA

Zhang, X., J. Zhang, , Y. Park, K.Y., Zhu (2012) Identification and characterization of two chitin synthase genes in African malaria mosquito, Anopheles gambiae. Insect Biochem. Mol. Biol. 42: 674-682.

Goodman, C., D. Stanley, J. Ringbauer, R. W. Beeman, K. Silver, and Y. Park (2012) A cell line derived from the red flour beetle Tribolium castaneum (Coleoptera: Tenebrionidae). In Vitro Cell. Dev. Biol. 48: 426-433.

Lu, Y., Y. Park, X. Gao1, X. Zhang, J. Yao, Y-P. Pang, H. Jiang, and K. Y. Zhu (2012) Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum. Scientific Reports 2:288 doi:10.1038/srep00288

Lu, Y., Y-P. Pang, Y. Park, X. Gao1, J. Yao, X. Zhang, and K. Y. Zhu (2012) Genome organization, phylogenies, expression patterns, and three dimensional protein models of two acetylcholinesterase genes from the red flour beetle. PLoS ONE 7(2): e32288. doi:10.1371/journal.pone.0032288

Park, Y.(2012)Endocrine regulation of insect diuresis in the early postgenomic era. Canadian Journal of Zoology 90:507-520.

Chaudhari, S. S., Y. Arakane, C. A. Specht, B Moussian, D. Boyle, Y. Park, K. J. Kramer, R. W. Beeman, S. Muthukrishnan (2011) The Knickkopf protein protects and organizes chitin in the newly synthesized insect exoskeleton. Proc. Nat. Aca. Sci. USA. 108:17028-17033.

Lu, Y., R. W. Beeman, J. F. Campbell, Y. Park, M. J. Aikins, J. Mori, K. Akasaka, T. W. Phillips (2011) Anatomical localization of stereoisomeric composition of Tribolium castaneum aggregation pheromone. Naturwissenschaften 98: 755-761.

Li, B., R. W. Beeman, and Y. Park (2011) Functions of duplicated genes encoding CCAP receptors in the red flour beetle Tribolium castaneum. J. Ins. Phys. 57: 1190-1197.

Šimo, L., J. Koči, Z. Dušan, and Y. Park (2011) Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. PLoS ONE 6(1):e16158.

Wang, J. , G. S. Simmons, T. A. Miller, B. E. Tabashnik, Y. Park (2011)Global Variation in the piggyBac-like Element of Pink Bollworm, Pectinophora gossypiella. J. Asian Pacific Entomology 14: 131-135.

Wang, J., E. D. Miller, Y. Park (2011) Characterization of mariner-like elements belonging to the cecropia subfamily in two closely related Helicoverpa species. Insect Science DOI 10.1111/j.1744-7917.2010.01389.x

Šimo, L., D. Zitnan, and Y. Park (2011) Neural control of salivary glands in ixodid ticks. Journal of Insect Physiology 58:459-466.

2005 - 2010

Paluzzi, J-P., Y. Park, R. J. Nachman, and I. Orchard (2010) Isolation, expression analysis, and functional characterization of the first antidiuretic hormone receptor in insects. Proc. Nat. Aca. Sci. USA. 107: 10290-10295.

Wang, J., E. D. Miller, G. S. Simmons, T. A. Miller, B. E. Tabashnik, Y. Park (2010) PiggyBac-like elements in the pink bollworm, Pectinophora gossypiella. Insect Molec. Biol. 19: 177-184.

Kim, H. S., T. Murphy, J. Xia, D. Caragea, Y. Park, R. Beeman, M. Lorenzen, J. Manak, S. Butcher, and S. Brown (2010) BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum. Nucleic Acid Research 38: D437-D442.

Shrestha, S., Y. Park, D. Stanley, Y. Kim (2010) Genes encoding phospholipases A2 mediate insect nodulation reactions to bacterial challenge. J. Ins. Phys. 56 324-332.

Ladislav R., I. Žitanová, L. Dai, L. Šimo, Y. Park, H. Satake, Y. Tanaka, M. E. Adams, and D. Žitnan (2009) Ecdysis triggering hormone signaling in arthropods. Peptides 31: 429-441.

Park, Y., and M. E. Adams (2010) Addendum: Insect G protein-coupled receptors. In Insect Pharmacology. (eds. L. I. Gilbert, T. Iatrou, and S. Gill) 360-362.

Begum, K., B. Li, R. W. Beeman, and Y. Park (2009) Functions of ion transport peptide and ion transport peptide-like in the red flour beetle Tribolium castaneum. Insect Biochem. Mol. Biol. 39: 717-725.

Šimo, L., D. Žitnan, and Y. Park (2009)Two novel neuropeptides in innervation of the salivary glands of the blacklegged tick Ixodes scapularis: Myoinhibitory peptides and SIF amide. J. Comparative Neurology. 517: 551-563. This article is with the cover picture of the issue.

Arakane, Y., R. Dixut, K. Begum, Y. Park, C. A. Specht, H. Merzendorfer, K. J. Kramer, S. Muthukrishnan, R. W. Beeman (2009) Analysis of functions of the chitin deacetylase gene family in Tribolium castaneum. Insect Biochem. Mol. Biol. 39: 355-365.

Šimo, L., M. Slovák, Y. Park and D. Žitnan (2009)Identification of a complex peptidergic neuroendocrine network in the hard tick, Rhipicephalus appendiculatus. Cell and Tissue Research 335: 639-655.

Arakane, Y., B. Li, S. Muthukrishnan, R. W. Beeman, K. J. Kramer, and Y. Park (2008) Functional analysis of four neuropeptides, EH, ETH, CCAP and bursicon, and their receptors in adult ecdysis behavior of the red flour beetle, Tribolium castaneum. Mechanisms of Development 125: 984-995.

Aikins, J. M., D. A. Schooley, K. Begum, R. W. Beeman, and Y. Park (2008) Vasopressin-like peptide and its receptor function in an indirect diuretic signaling pathway in the red flour beetle. Insect Biochem. Mol. Biol. 38: 740-748.

Lorenzen, M. D., A. Gnirke, J. Margolis, M. Campbell, J. J. Stuart, S. Richards, Y. Park, and R. W. Beeman (2008) The maternal-effect, selfish genetic element Medea in Tribolium is a Tc1 transposon. Proc. Nat. Aca. Sci. USA. 105:10085-10089.

Richards, S. et al. (Tribolium genome sequencing consortium) (2008) The first genome sequence of a beetle, Tribolium castaneum, a model for insect development and pest biology. Nature 452: 949-955.

Siebert, K., M. D. Lorenzen, S. J. Brown, Y. Park, and R. W. Beeman (2008) Tubulin superfamily genes in Tribolium castaneum, and use of a Tubulin promoter to drive transgene expression. Insect Biochem. Mol. Biol. 38: 749-755.

Mutti,N. S., J. Louis, L. K. Pappan, K. Pappan, K. Begum, M-S. Chen, Y. Park, N. Dittmer, J. Marshall, J. C. Reese and G. R. Reeck(2008) A novel protein from the salivary glands of the pea aphid, Acyrthosiphon pisum, is essential in feeding on host plants. Proc. Nat. Aca. Sci. USA. 105: 965-9969.

Wang J., C-C., W., S. Brown, and Y. Park (2008) Large diversity of piggyBac-like element PLE families in the genome of Tribolium castaneum. Insect Biochem. Mol. Biol. 38: 490-498.

Park, Y. J. Aikins, L.J. Wang, R. W. Beeman, B. Oppert, J. C. Lord, S. J. Brown, M. D. Lorenzen, S. Richards, G M. Weinstock, and R A. Gibbs (2008) Analysis of transcriptome data in the red flour beetle Tribolium castaneum. Insect Biochem. Mol. Biol. 38: 380-386.

Hauser, F., G. Cazzamali, M. Williamson, Y. Park, B. Li, Y. Tanaka, R. Predel, S. Neupert, J. Schachtner, P. Verleyen, and C. J. P. Grimmelikhuijzen (2008) Genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum. Frontiers in neuroendocrinology 29: 142-165.

Li, B., R. Predel, S. Neupert, F. Hauser, Y. Tanaka, G. Cazzamali, M. Williamson, P. Verleyen, L Schoofs, J. Schachtner, C. J. P. Grimmelikhuijzen, and Y. Park (2008) Genomics, transcriptomics, and peptidomics of peptide and protein hormones in the red flour beetle Tribolium castaneum. Genome Research 18: 113-122.

Park, Y., and R. W. Beeman (2008) Postgenomics of Tribolium: targeting the endocrine regulation of diuresis. Entomological Research. 38:93-100.

Konakandla, B., Y. Park, and D. Margolies. (2006) Whole genome amplification of Chelex-extracted DNA from a single mite: A method for studying genetics of the predatory mite Phytoseiulus persimilis. Experimental and Applied Acarology, 40: 241-247.

Ren, X., Y. Park, and T. A. Miller. (2006) Intact mariner-like element in tobacco budworm, Heliothis virescens (Lepidoptera: Noctuidae). Insect Mol. Biol. 15: 743-748.

Wang, J., T. A. Miller, and Y. Park (2006) Development of multiple dominant markers by using Vectorette PCR-based non-radioactive transposable element display. Mol. Ecology Notes 6: 642-645.

Wang, J., R. Xiaoxia, T. A. Miller, and Y. Park (2006) PiggyBac-like elements PLE in the tobacco budworm, Heliothis virescens (Fabricius). Insect Mol. Biol. 15: 435-443.

Mutti, N. S., Y. Park, J. C. Reese, and G. R. Reeck (2006) RNAi-knockdown of a salivary transcript leading to lethality in the pea aphid (acyrthosiphon pisum). J. Insect Science 6.38.

Maddur, A. A., X. Liu, Y. C. Zhu, J. P. Fellers, B. Oppert, Y. Park, J. Bai. G. E. Wilde, and M. S. Chen (2006) Cloning and characterization of protease inhibitor-like cDNAs from the Hessian fly Mayetiola destructor (SAY). Insect Mol. Biol. 15: 485-496.

Adams, M. E., Y-J. Kim, Y. Park, and D. Zitnan (2006) Developmental peptides: ETH, corazonin and PTTH. In Handbook of biologically active peptides. (ed. A. Kastin), San Diego: Academic Press Elsevier, pp. 163-169.

Wang, J., R. Staten, T. A. Miller, and Y. Park (2005) Inactivated mariner-like transposable elements MLE in pink bollworm, Pectinophora gossypiella, Insect Mol. Biol. 14: 547-553.

Park, Y., and M. E. Adams (2005) Insect G protein-coupled receptors. In Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology. (eds. L. I. Gilbert, T. Iatrou, and S. Gill) 5: 143-171.

Before 2005

Kim, Y. J., I. Spalivska-Valachova, K-H Cho, I. Žitanová, Y. Park, M. E. Adams, and D. Žitnan (2004) Corazonin receptor signaling in ecdysis initiation. Proc. Nat. Aca. Sci. USA. 101: 6704-6709.

Park, Y., Y. J. Kim, V. Dupriez, and M. E. Adams (2003) Two subtypes of ecdysis-triggering hormone receptor in Drosophila melanogaster, J. Biol. Chem. 278: 17710-17715.

Žitnan, D., I. Žitnanová, I. Spalovska, P. Takac, Y. Park, and M. E. Adams (2003) Conservation of ecdysis triggering hormone signaling in insects. J. Exp. Biol. 206: 1275-1289.

Park, Y., Y. J. Kim, and M. E. Adams (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor co-evolution. Proc. Nat. Aca. Sci. USA. 99: 11423-11428.

Park, Y., V. Filippov, S. S. Gill, and M. E. Adams (2002) Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Development 129: 493-503.

Loi, P.K., S. A. Emmal, Y. Park, and N. J. Tublitz (2001) Identification, sequence and expression of a crustacean cardioactive peptide (CCAP) gene in the moth Manduca sexta. J. Exp. Biol. 204: 2803-2816.

Zhao. Y, Y. Park, and M. E. Adams (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. Biochem. Biophys. Res. Comm. 278:516-521.

Park, Y., D. Lee, M. F. J. Taylor, J. Holloway, J. A. Ottea, M. E. Adams, and R. Feyereisen (2000) Characterization of L1029H mutation in the sodium channel for pyrethroid resistance in Heliothis virescens F. Pestic. Biochem. Physiol. 66: 1-8.Park, Y., D. Žitnan, S. S. Gill, and M. E. Adams (1999) Molecular cloning and biological activity of ecdysis triggering hormone (ETH) in Drosophila melanogaster. FEBS Letters 463: 133-138.

Lee, D, Y. Park, T. M. Brown, and M. E. Adams (1999) Altered property of neuronal sodium channels associated with resistance to pyrethroid insecticide. Molec. Pharmacol. 55: 584-593

Park, Y., M. F. J. Taylor, and R. Feyereisen (1999) Genomic structure of para homologous voltage-gated sodium channel in Heliothis virescens F. Insect Molec. Biol. 8: 162-170.

ffrench-Constant, R., Y. Park., and R. Feyereisen (1998) Molecular biology of insecticide resistance. In Molecular Biology of Toxic Response. (eds. A. Puga and K. Wallace) Taylor and Francis, Inc. Philadelphia pp. 533-551

Park, Y., M. F. J. Taylor, and R. Feyereisen (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with pyrethroid resistance in Heliothis virescens F. Biochem. Biophys. Res. Comm. 239: 688-691.

Park, Y. and M. F. J. Taylor (1997) A novel mutation L1029H in sodium channel gene hscp associated with pyrethroid resistance for Heliothis virescens (Lepidoptera: Noctuidae). Insect Biochem. Molec. Biol. 27: 9-13.

Taylor, M. F. J., Y. Park, and Y. Shen (1996) Molecular population genetics of sodium channel and JH esterase markers in relation to pyrethroid resistance in Heliothis virescens (Lepidoptera: Noctuidae). Ann. Entomol. Soc. Am. 89: 728-738.