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Department of Entomology

Department of Entomology
123 W. Waters Hall
1603 Old Claflin Place
Kansas State University
Manhattan KS 66506-4004

785-532-6232 fax

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Silver, Kristopher

Ruberson, John

Associate Professor

Department of Entomology

106 Waters Annex

Kansas State University

Manhattan, KS  66506

Phone:785 532-4752


E-mail: ksilver@ksu.edu






1999-2005       Ph.D. Environmental Toxicology, Cornell University, Ithaca, New York.

1995-1999       B.S. Biology, Moravian College, Bethlehem, PA.



Research Interests:

My research interests broadly encompass the physiological and molecular interactions between insects and insecticides. Particular emphasis is currently on mechanisms of RNA interference and uptake of double-stranded RNA in addition to insecticides targeting voltage-gated sodium channels.


Recent Publications:

Silver, KS, B. Zhorov, K. Dong. 2017. Molecular mechanism of action and selectivity of sodium channel blocker insecticides. Current Medicinal Chemistry 23. Epub.

Silver, KS, A Littlejohn, L Thomas, E Marsh, JD Lillich. 2015. Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration. Biochemical Pharmacology 98: 614-628.

Silver, KS, H Jiang, JP Fu, TW Phillips, RW Beeman, Y Park. 2014. The Tribolium castaneum cell line, TcA:a new tool kit for cell biology. Scientific Reports 4: 6840.

Dong, K, Y Du, F Rinkevich, Y Nomura, P Xu, L Wang, KS Silver, BS Zhorov. 2014. Molecular Biology of Insect Sodium Channels and Pyrethroid Resistance. Insect Biochemistry and Molecular Biology.50: 1-17.

Silver, KS, Y Du, Y Nomura, EE Oliviera, VL Salgado, B Zhorov, K Dong. 2014. Voltage-gated sodium channels as insecticide targets. In E. Cohen, editor: Target receptors in the control of insect pests: Part II, Vol 46, Advances in Insect Physiology, UK: Academic Press, p. 389-433.

von Stein, F, KS Silver, DM Soderlund. 2013. Indoxacarb, Metaflumizone, and Other Sodium Channel Inhibitor Insecticides: Mechanism and Site of Action on Mammalian Voltage-Gated Sodium Channels. Pesticide Biochemistry and Physiology 106: 101-112.

Goodman CL, D Stanley, JA Ringbauer Jr, RW Beeman, KS Silver, Y Park. 2012. A cell line derived from the red flour beetle Tribolium castaneum (Coleoptera: Tenebrionidae).In Vitro Cellular & Developmental BiologyAnimal48: 426-433.

Silver, KS, A Desourmaux, LC Freeman, and JD Lillich. 2012. Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs.  Growth Factors 30: 258-266.

Lillich, JD, W Ray-Miller, KS Silver, E Davis, and BD Schultz. 2011.  Intra-abdominal hyaluronan concentration in peritoneal fluid of horses with sudden signs of severe abdominal pain.  American Journal of Veterinary Research.  72:  1666-1673.

Song, W, KS Silver*, Y Du, Z Liu, K Dong.  2011.  Analysis of the action of lidocaine on insect sodium channels.  Insect Biochemistry and Molecular Biology 41:  36-41.

Silver, KS, L Leloup, LC Freeman, A Wells, JD Lillich.  2010.  Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease.  International Journal of Biochemistry and Cell Biology 42:  2030-2036.

Silver, KS, W Song, Y Nomura, V Salgado, K Dong.  2010. Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels.  Pesticide Biochemistry and Physiology 97:  87-92.