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Kristopher SilverAssociate Professor & Director of Integrated Department of Entomology |
Education:
- 1999-2005 Ph.D. Environmental Toxicology, Cornell University, Ithaca, New York.
- 1995-1999 B.S. Biology, Moravian College, Bethlehem, PA.
Research Interests:
My research interests broadly encompass the physiological and molecular interactions between insects and insecticides. Particular emphasis is currently on mechanisms of RNA interference and uptake of double-stranded RNA in addition to insecticides targeting voltage-gated sodium channels.
Recent Publications:
Silver, KS, B. Zhorov, K. Dong. 2017. Molecular mechanism of action and selectivity of sodium channel blocker insecticides. Current Medicinal Chemistry 23. Epub.
Silver, KS, A Littlejohn, L Thomas, E Marsh, JD Lillich. 2015. Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration. Biochemical Pharmacology 98: 614-628.
Silver, KS, H Jiang, JP Fu, TW Phillips, RW Beeman, Y Park. 2014. The Tribolium castaneum cell line, TcA:a new tool kit for cell biology. Scientific Reports 4: 6840.
Dong, K, Y Du, F Rinkevich, Y Nomura, P Xu, L Wang, KS Silver, BS Zhorov. 2014. Molecular Biology of Insect Sodium Channels and Pyrethroid Resistance. Insect Biochemistry and Molecular Biology.50: 1-17.
Silver, KS, Y Du, Y Nomura, EE Oliviera, VL Salgado, B Zhorov, K Dong. 2014. Voltage-gated sodium channels as insecticide targets. In E. Cohen, editor: Target receptors in the control of insect pests: Part II, Vol 46, Advances in Insect Physiology, UK: Academic Press, p. 389-433.
von Stein, F, KS Silver, DM Soderlund. 2013. Indoxacarb, Metaflumizone, and Other Sodium Channel Inhibitor Insecticides: Mechanism and Site of Action on Mammalian Voltage-Gated Sodium Channels. Pesticide Biochemistry and Physiology 106: 101-112.
Goodman CL, D Stanley, JA Ringbauer Jr, RW Beeman, KS Silver, Y Park. 2012. A cell line derived from the red flour beetle Tribolium castaneum (Coleoptera: Tenebrionidae). In Vitro Cellular & Developmental Biology – Animal48: 426-433.
Silver, KS, A Desourmaux, LC Freeman, and JD Lillich. 2012. Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs. Growth Factors 30: 258-266.
Lillich, JD, W Ray-Miller, KS Silver, E Davis, and BD Schultz. 2011. Intra-abdominal hyaluronan concentration in peritoneal fluid of horses with sudden signs of severe abdominal pain. American Journal of Veterinary Research. 72: 1666-1673.
Song, W, KS Silver*, Y Du, Z Liu, K Dong. 2011. Analysis of the action of lidocaine on insect sodium channels. Insect Biochemistry and Molecular Biology 41: 36-41.
Silver, KS, L Leloup, LC Freeman, A Wells, JD Lillich. 2010. Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. International Journal of Biochemistry and Cell Biology 42: 2030-2036.
Silver, KS, W Song, Y Nomura, V Salgado, K Dong. 2010. Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels. Pesticide Biochemistry and Physiology 97: 87-92.